|
Symbol Name ID |
Mib1
MIB E3 ubiquitin protein ligase 1 MGI:2443157 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Ventricular septal defect |
Left ventricular hypertrophy |
Left ventricular noncompaction |
Noncompaction cardiomyopathy |
Left ventricular noncompaction cardiomyopathy |
Hypoplastic left heart |
Patent ductus arteriosus |
Mitral regurgitation |
Sudden cardiac death |
Palpitations |
Atrial fibrillation |
Ventricular arrhythmia |
First degree atrioventricular block |
Congestive heart failure |
| Disease(s) Associated with MIB1 | ||||||||||||||
| left ventricular noncompaction |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal blood vessel morphology |
abnormal dorsal aorta morphology |
poor arterial differentiation |
abnormal aorta morphology |
abnormal intersomitic vessel morphology |
absent intersomitic vessels |
abnormal angiogenesis |
abnormal vascular regression |
abnormal vitelline vasculature morphology |
absent vitelline blood vessels |
abnormal trabecula carnea morphology |
thin left ventricle myocardium compact layer |
abnormal cardiac outflow tract development |
abnormal heart looping |
failure of heart looping |
small heart |
abnormal aortic valve morphology |
bicuspid aortic valve |
dilated heart ventricle |
pericardial edema |
distended pericardium |
pericardial effusion |
cardiac fibrosis |
abnormal blood circulation |
decreased cardiac muscle contractility |
aortic valve regurgitation |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||
| Mib1tm1Art/Mib1tm1Art | ||||||||||||||||||||||||||||
| Mib1tm1Kong/Mib1tm1Kong | ||||||||||||||||||||||||||||
| Mib1tm2Kong/Mib1tm2Kong Tg(Tek-cre)12Flv/0 (conditional) |
* | |||||||||||||||||||||||||||
| Mib1em1Jlp/Mib1tm2Kong Tg(Tnnt2-cre)5Blh/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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